Aging is an inevitable process in most multicellular organism that is regulated by both genetic and environmental factors. Multiple pathways have been discovered using the nematode species Caenorhabditis elegans which were then shown to be conserved in other higher eukaryotes. Simultaneously gene expression profiling using C. elegans during aging, revealed the identification of age-dependent gene expression alterations that characterize the nematode’s ageing process. Following this, multiple studies led to the construction of genetic and molecular networks that includes well-known aging regulators.
In this paper by Aktypi et al (2021), the authors used a novel approach that revealed candidates which were never been linked to ageing before, thus suggesting promising potential targets/ageing regulators. More specifically, they have combined microarray gene expression profiling of the wild type animals during ageing with network analysis of the differentially expressed genes to detect regulatory genes that have importance in C. elegans ageing, an approach that has not been applied before for the detection of ageing regulators.
Aktypi, F. et al. (2021) Network analysis in aged C. elegans reveals candidate regulatory genes of ageing. Biogerontology. (https://doi.org/10.1007/s10522-021-09920-3)