{"id":348,"date":"2019-12-13T20:09:55","date_gmt":"2019-12-14T01:09:55","guid":{"rendered":"http:\/\/www.briggsae.org\/?page_id=348"},"modified":"2019-12-14T19:07:35","modified_gmt":"2019-12-15T00:07:35","slug":"about-c-briggsae","status":"publish","type":"page","link":"https:\/\/www.briggsae.org\/?page_id=348","title":{"rendered":"About C. briggsae"},"content":{"rendered":"\n<p>The nematode <em>Caenorhabditis briggsae<\/em> (<em>C. briggsae)<\/em> is a natural companion to <em>C. elegans<\/em> for research because of the similarities in morphology, hermaphroditic  life style and ease of cultivation. The two nematode species diverged from a  common ancestor less than 30 million years ago (Cutter, 2008) yet appear  almost identical in morphology. The phylogenetic relationships of <em>Caenorhabditis<\/em> nematodes reveals that <em>C. briggsae<\/em> and <em>C. elegans<\/em> are not sibling species and that <em>C. nigoni<\/em>, a gonochoristic species, is the closest relative of <em>C. briggsae<\/em>  (see Felix et al., PLoS ONE, DOI: <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0094723\">10.1371\/journal.pone.0094723<\/a>). The  seemingly identical morphology of the two nematodes permits  straightforward interpretation of results involving conserved genes and  pathways. <\/p>\n\n\n\n<p>The genome sequence and chromosome assembly of <em>C. briggsae<\/em>  (Stein et al. 2003, Hillier et al. 2007) are valuable in reverse  genetics and genome-wide comparative studies. The majority of the  currently available genetic and reverse genetic tools in <em>C. elegans<\/em> can be used in <em>C. briggsae<\/em> with no major modification. These resources make <em>C. briggsae<\/em> an ideal model for comparative studies. The whole genome sequencing and assembly projects revealed that the genomes of <em>C. briggsae<\/em> and <em>C. elegans<\/em>  have much in common. For example, both worms have the same number of  chromosomes (six chromosomes each), similar genome size, and similar  numbers of protein coding and non-protein coding genes. Further analysis  demonstrated that about two-third of the protein coding genes in <em>C. briggsae<\/em> have orthologs in <em>C. elegans<\/em>.  Nevertheless, many interesting species-specific features including  species-specific genes exist, which serve as the foundation for  comparative and evolutionary studies.   <\/p>\n\n\n\n<p><em>(Modified from the  Wormbook chapter &#8220;Genomics and biology of the nematode Caenorhabditis  briggsae&#8221; by B. Gupta, R. Johnsen, and N. Chen. Some contents are based on other published papers.)<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The nematode Caenorhabditis briggsae (C. briggsae) is a natural companion to C. elegans for research because of the similarities in morphology, hermaphroditic life style and ease of cultivation. The two nematode species diverged from a common ancestor less than 30 million years ago (Cutter, 2008) yet appear almost identical in morphology. The phylogenetic relationships of &hellip; <a href=\"https:\/\/www.briggsae.org\/?page_id=348\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"class_list":["post-348","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/pages\/348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=348"}],"version-history":[{"count":3,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/pages\/348\/revisions"}],"predecessor-version":[{"id":414,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/pages\/348\/revisions\/414"}],"wp:attachment":[{"href":"https:\/\/www.briggsae.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}