{"id":624,"date":"2021-04-25T22:27:28","date_gmt":"2021-04-26T02:27:28","guid":{"rendered":"http:\/\/www.briggsae.org\/?p=624"},"modified":"2021-04-25T22:27:28","modified_gmt":"2021-04-26T02:27:28","slug":"let-7-microrna-absent-in-many-caenorhabditis-nematodes","status":"publish","type":"post","link":"https:\/\/www.briggsae.org\/?p=624","title":{"rendered":"let-7 microRNA absent in many Caenorhabditis nematodes"},"content":{"rendered":"\n<p>A recent paper by Nelson and Ambros [1] reports that <em>let-7<\/em>\u00a0heterochronic microRNA is absent in <em>Caenorhabditis<\/em> species of the <em>japonica<\/em> group. Research in <em>C. elegans<\/em> has shown that <em>let-7<\/em> plays an essential role during larval to adult transition and mutations in <em>let-7<\/em> cause lethality. Authors used one species of the <em>japonica<\/em> group, <em>C. sulstoni<\/em>, to further investigate microRNA gene regulatory network. The results revealed that the loss of <em>let-7<\/em> function in this species is compensated by other <em>let-7<\/em> family members, i.e., <em>miR-48, miR- 84,<\/em> and <em>miR-241<\/em>. <\/p>\n\n\n\n<p>Considering that <em>let-7<\/em>\u00a0is highly conserved across bilaterians [2], the results presented in this paper are exciting. However, more work is needed to understand the basis of such an evolutionary change and other potential changes in microRNA-mediated processes.<\/p>\n\n\n\n<p><strong>Reference: <br><\/strong>1. Nelson C. and Ambros V. (2021). A cohort of\u00a0<em>Caenorhabditis<\/em>\u00a0species lacking the highly conserved\u00a0<em>let-7<\/em>\u00a0microRNA. G3,\u00a011(3), jkab022. DOI: 10.1093\/g3journal\/jkab022. <br><br>2. Pasquinelli A.E. et al.\u00a0(2000). Conservation of the sequence and temporal expression of <em>let-7<\/em> heterochronic regulatory RNA. Nature. 408:86\u201389.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent paper by Nelson and Ambros [1] reports that let-7\u00a0heterochronic microRNA is absent in Caenorhabditis species of the japonica group. Research in C. elegans has shown that let-7 plays an essential role during larval to adult transition and mutations in let-7 cause lethality. Authors used one species of the japonica group, C. sulstoni, to &hellip; <a href=\"https:\/\/www.briggsae.org\/?p=624\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"categories":[20],"tags":[33,32],"class_list":["post-624","post","type-post","status-publish","format-standard","hentry","category-news","tag-let-7","tag-microrna"],"_links":{"self":[{"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/posts\/624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=624"}],"version-history":[{"count":1,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/posts\/624\/revisions"}],"predecessor-version":[{"id":625,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=\/wp\/v2\/posts\/624\/revisions\/625"}],"wp:attachment":[{"href":"https:\/\/www.briggsae.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.briggsae.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}